Triethylamine → {4-[(3-Sulfonylmethylpyridyl)amino]-2-phenylbenzoyl}methionine methyl ester

HRID 325235노트

반응식

HRID 325235 반응식
Cl.Cl[S:3]([CH2:6][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)(=[O:5])=[O:4].[CH3:13][O:14][C:15](=[O:37])[C@H:16]([CH2:33][CH2:34][S:35][CH3:36])[NH:17][C:18](=[O:32])[C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][C:20]=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.C(N(CC)CC)C>ClCCl.C(OCC)(=O)C>[CH3:13][O:14][C:15](=[O:37])[C@H:16]([CH2:33][CH2:34][S:35][CH3:36])[NH:17][C:18](=[O:32])[C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:8]2[C:7]([CH:6]=[S:3](=[O:5])=[O:4])=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:21][C:20]=1[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 18666758N-(4-Amino-2-phenylbenzoyl)methionine methyl esterHCID 23436466(Pyridin-3-yl)methanesulfonyl chloride hydrochloride

생성물 1

HCID 20622808{4-[(3-Sulfonylmethylpyridyl)amino]-2-phenylbenzoyl}methionine methyl ester

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 3-chlorosulfonylmethylpyridine hydrochloride (1.0 equivalent) and (4-amino-2-phenylbenzoyl)methionine methyl ester (1.0 equivalent) in dichloromethane is treated with triethylamine (2.2 equivalents). When judged complete by TLC analysis, the reaction is diluted with ethyl acetate, and then is washed with pH 4 water, saturated NaHCO3, and brine. The mixture is dried and concentrated to give the crude title compound which is purified by chromatography on silica gel.

후처리

  1. washis washed with pH 4 water, saturated NaHCO3, and brine
  2. customThe mixture is dried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d0f29433db464e24bea847ca7d7cf310
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06221865B1

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