Hexane → HCID 13083046, compound

HRID 325255Notes

Reaction equation

HRID 325255 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([O:10][CH3:11])[N:3]=1.[Cl:12][CH:13]([CH3:21])[CH2:14][S:15]([N:18]=[C:19]=[O:20])(=[O:17])=[O:16].CCCCCC>ClCCl>[CH3:9][O:8][C:6]1[N:5]=[C:4]([O:10][CH3:11])[N:3]=[C:2]([NH:1][C:19]([NH:18][S:15]([CH2:14][CH:13]([Cl:12])[CH3:21])(=[O:17])=[O:16])=[O:20])[N:7]=1

Participants

5

Reactant 3

HCID 8058HexaneHCID 278402-Amino-4,6-dimethoxy-1,3,5-triazineHCID 13548028HCID 13548028, compound

Product 1

HCID 13083046HCID 13083046, compoundYield 90.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

15.6 g (0.1 mole) of 2-amino-4,6-dimethoxy-1,3,5-triazine were suspended in 150 ml of dichloromethane, and a solution of 19.5 g (0.106 mole) of 2-chloro-n-prop-1-yl-sulfonyl isocyanate in 100 ml of dichloromethane was added at 0° C., while stirring. The mixture was further stirred for 12 hours at room temperature and cooled to 0° C., and 300 ml of n-hexane were added. The precipitated reaction product was filtered off under suction, washed with n-hexane and dried. 30.7 g (90.5% of theory) of N-(4,6-dimethoxy-1,3,5-triazin-2-yl)-N'-(2-chloro-n-prop-1-yl-sulfonyl)-urea of melting point 139°-41° C. were obtained.

Workup

  1. stirringThe mixture was further stirred for 12 hours at room temperature
  2. customThe precipitated reaction product
  3. filtrationwas filtered off under suction
  4. washwashed with n-hexane
  5. customdried

Sources & evidence

ORD record
ord-db69acafbf45451ba9327d3dfb4c4472
Source dataset
uspto-grants-1984_04
Patent number
US04440565

Reaction notes

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