Sodium Hydroxide → HCID 13083048, compound

Participants

Reaction Conditions

Reaction Steps

14.6 g (0.05 mole) of N-(4,6-dimethyl-pyrimidin-2-yl)-N'-(2-chloro-eth-1-yl-sulfonyl)-urea (cf. Example 12) were dissolved in 150 ml of ethanol, and 4 g (0.1 mole) of sodium hydroxide, dissolved in 10 ml of water, were added at room temperature. The reaction mixture was then warmed to 40° C. for 4 hours, concentrated in vacuo and taken up in 150 ml of water. After acidification with 2 N HCl (pH 5), the mixture was extracted with ethyl acetate, and the extracts were then dried and concentrated. After the addition of n-hexane, 8.9 g (69.5% of theory) of N-(4,6-dimethyl-pyrimidin-2-yl)-N'-(vinylsulfonyl)-urea of melting point 131°-3° C. were obtained.

Provenance & Evidence