6-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine → 6-[1-(3,4-Dimethoxybenzyl)-4-phenyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine

HRID 32526Notes

Reaction equation

HRID 32526 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH2:6][N:7]1[C:11]([C:12]2[S:24][C:15]3[N:16]=[CH:17][N:18]=[C:19](S(C)(=O)=O)[C:14]=3[CH:13]=2)=[C:10]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:9]=[CH:8]1.C[N:37]1C(C2SC3N=CN=C(S(C)(=O)=O)C=3C=2)=C(C2C=CC=CC=2)N=C1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH2:6][N:7]1[C:11]([C:12]2[S:24][C:15]3[N:16]=[CH:17][N:18]=[C:19]([NH2:37])[C:14]=3[CH:13]=2)=[C:10]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:9]=[CH:8]1

Participants

3

Reactant 2

HCID 179657746-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidineHCID 179657826-[1-(3,4-Dimethoxybenzyl)-4-phenyl-1H-imidazol-5-yl]-4-(methylsulfonyl)thieno[2,3-d]pyrimidine2×

Product 1

HCID 100264296-[1-(3,4-Dimethoxybenzyl)-4-phenyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine

Procedure

The title compound was prepared by a similar process to that described for Example 8 but using 6-[1-(3,4-dimethoxybenzyl)-4-phenyl-1H-imidazol-5-yl]-4-(methylsulfonyl)-thieno[2,3-d]pyrimidine (intermediate 19) in place of 6-(1-methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine (intermediate 17). White solid (35 mg, 91%);

Sources & evidence

ORD record
ord-5535ef57f2bd47fb88fc5c7fd04bdd3b
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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