6-[1-(3,4-Dimethoxybenzyl)-4-phenyl-1H-imidazol-5-yl]-4-(methylthio)thieno[2,3-d]pyrimidine → 6-[1-(3,4-Dimethoxybenzyl)-4-phenyl-1H-imidazol-5-yl]-4-(methylsulfonyl)thieno[2,3-d]pyrimidine

HRID 32527Notes

Reaction equation

HRID 32527 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[S:19][C:10]3[N:11]=[CH:12][N:13]=[C:14]([S:15]([CH3:18])(=[O:17])=[O:16])[C:9]=3[CH:8]=2)=[C:5]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:4]=[CH:3]1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]([CH:54]=[CH:55][C:56]=1[O:57][CH3:58])CN1C(C2SC3N=CN=C(SC)C=3C=2)=C(C2C=CC=CC=2)N=C1>>[CH3:26][O:27][C:28]1[CH:29]=[C:30]([CH:54]=[CH:55][C:56]=1[O:57][CH3:58])[CH2:1][N:2]1[C:6]([C:7]2[S:19][C:10]3[N:11]=[CH:12][N:13]=[C:14]([S:15]([CH3:18])(=[O:17])=[O:16])[C:9]=3[CH:8]=2)=[C:5]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:4]=[CH:3]1

Participants

3

Reactant 2

HCID 179657606-[1-(3,4-Dimethoxybenzyl)-4-phenyl-1H-imidazol-5-yl]-4-(methylthio)thieno[2,3-d]pyrimidineHCID 179657746-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine

Product 1

HCID 179657826-[1-(3,4-Dimethoxybenzyl)-4-phenyl-1H-imidazol-5-yl]-4-(methylsulfonyl)thieno[2,3-d]pyrimidineYield 75%

Procedure

The title compound was prepared in 75% yield according to a procedure similar to the one described for intermediate 17 above but starting from 6-[1-(3,4-dimethoxybenzyl)-4-phenyl-1H-imidazol-5-yl]-4-(methylthio)thieno[2,3-d]pyrimidine (example 9) in place of 6-(1-methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine (example 7);

Sources & evidence

ORD record
ord-98dcbf7e8ba847ae99b5f9d0b9434876
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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