Methylhydrazine → HCID 13059392, compound

HRID 325338Notes

Reaction equation

HRID 325338 reaction equation
C[O:2][C:3](=O)[C@H:4]([CH2:9][S:10][CH3:11])[NH:5][C:6](=[O:8])[CH3:7].[CH3:13][NH:14][NH2:15]>C(O)C>[CH3:13][N:14]([C:3](=[O:2])[C@H:4]([CH2:9][S:10][CH3:11])[NH:5][C:6](=[O:8])[CH3:7])[NH2:15]

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 13059384HCID 13059384, compound

Product 1

HCID 13059392HCID 13059392, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 20 ml of ethyl alcohol was dissolved 1.91 g (10 mmole) of S-methyl-N-acetyl-L-cysteine methylester and 5.4 ml (100 mmole) of methylhydrazine was added. The mixture was stirred for 3 hours at boiling temperature and then allowed to stand for 1 day at room temperature. After the precipitate was removed, the ethyl alcohol and the excess methylhydrazine were distilled off in vacuo to leave crystals. Thus, 1.05 g (5.1 mmole) of N-methyl-N-(S-methyl-N-acetylcysteinyl)-hydrazine was obtained in 51% yield.

Workup

  1. additionwas added
  2. waitto stand for 1 day at room temperature
  3. customAfter the precipitate was removed
  4. distillationthe ethyl alcohol and the excess methylhydrazine were distilled off in vacuo
  5. customto leave crystals

Sources & evidence

ORD record
ord-64d2757d9f49417da0a4d8b8e930492a
Source dataset
uspto-grants-1984_04
Patent number
US04440788

Reaction notes

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