反应详情

A solution of 2-[4-(2.3-epoxypropoxy)phenyl]-4-trifluoromethylimidazole (1 g) in isopropylamine (10 ml.) is heated 7 hours at reflux and then allowed to stand 16 hours at room temperature. The excess isopropylamine is removed by distillation at atmospheric pressure and the residue is triturated with nitromethane to yield a solid. After filtration and recrystallization from acetonitrile, 0.6 g. of 2-[4-(3-isopropylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole is obtained, m.p. 173°-173.5° C.

1. temperatureat reflux
2. customThe excess isopropylamine is removed by distillation at atmospheric pressure
3. customthe residue is triturated with nitromethane
4. customto yield a solid
5. filtrationAfter filtration and recrystallization from acetonitrile, 0.6 g