Sodium Hydroxide → HCID 20254390, compound

HRID 325367Notes

Reaction equation

HRID 325367 reaction equation
[O:1]=[C:2]1[NH:6][C:5]([C:7](=[O:13])[C:8]([O:10]CC)=[O:9])=[CH:4][S:3]1.[OH-].[Na+]>>[O:1]=[C:2]1[NH:6][C:5]([C:7](=[O:13])[C:8]([OH:10])=[O:9])=[CH:4][S:3]1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 20254330HCID 20254330, compoundHCID 178473047HCID 178473047, compound

Product 1

HCID 20254390HCID 20254390, compound

Procedure

A mixture of ethyl 2-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)glyoxylate, which can be represented as ethyl 2-(2-hydroxy-1,3-thiazol-4-yl)glyoxylate, (1.45 g.) and 1 N sodium hydroxide aqueous solution (21 ml.) was allowed to stand for 30 minutes at room temperature. After the reaction, the reaction mixture was washed with diethyl ether and then adjusted to pH 1 with 10% hydrochloric acid. The precipitates were collected by filtration, washed with water and diethyl ether and dried to give powder of 2-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)glyoxylic acid, which can be represented as 2-(2-hydroxy-1,3-thiazol-4-yl)glyoxylic acid, (0.30 g.). On the other hand, the filtration was extracted with ethyl acetate, and the ethyl acetate was distilled off from the extract to give the same object compound (0.40 g.).

Workup

  1. customAfter the reaction
  2. washthe reaction mixture was washed with diethyl ether
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water and diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-bc348f3a023c4f57ae0b2f0fc286cf22
Source dataset
uspto-grants-1984_04
Patent number
US04440766

Reaction notes

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