Sodium Hydroxide → HCID 12961134, compound

HRID 325388Notes

Reaction equation

HRID 325388 reaction equation
[OH:1][CH:2]([C:6]1[S:10][C:9]([NH2:11])=[N:8][CH:7]=1)[C:3]([OH:5])=[O:4].[OH-].[Na+]>[O-2].[O-2].[Mn+4].O>[NH2:11][C:9]1[S:10][C:6]([C:2](=[O:1])[C:3]([OH:5])=[O:4])=[CH:7][N:8]=1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 13371224HCID 13371224, compoundHCID 178509088HCID 178509088, compound

Product 1

HCID 12961134HCID 12961134, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalyst2×HCID 962WaterSolvent

Procedure

A mixture of 2-hydroxy-2-(2-amino-1,3-thiazol-5-yl)acetic acid, which can be represented as 2-hydroxy-2-(2-imino-2,3-dihydro-1,3-thiazol-5-yl)acetic acid, (0.92 g.) and water (10 ml.) was adjusted to pH 7 to 7.5 with a 10% sodium hydroxide aqueous solution, and to the mixture was added manganese dioxide (1.74 g.) and then the mixture was stirred for 5 hours at 50° to 60° C. After the reaction, manganese dioxide was filtered off and then washed with a small amount of water. The filtrate and washing were combined together, adjusted to pH 1 with concentrated hydrochloric acid and then stirred for 15 minutes under ice-cooling. The precipitates were collected by filtration, washed with water and then dried to give 2-(2-amino-1,3-thiazol-5-yl)glyoxylic acid, which can be represented as 2-(2-imino-2,3-dihydro-1,3-thiazol-5-yl)glyoxylic acid, (0.53 g.), mp. 185° to 250° C. (dec.).

Workup

  1. filtrationwas filtered off
  2. washwashed with a small amount of water
  3. washThe filtrate and washing
  4. stirringstirred for 15 minutes under ice-
  5. temperaturecooling
  6. filtrationThe precipitates were collected by filtration
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-4c0e85708cae485eb400556dfa9f2fcb
Source dataset
uspto-grants-1984_04
Patent number
US04440766

Reaction notes

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