Hydrochloric Acid → HCID 86739343, compound

Participants

Reaction Steps

Ethyl 1,4,5,10-tetrahydro-7-chloro-3-ethoxycarbonyl-1-methyl-10-oxo-benzocyclohepta[1,2-b]-pyrrole-2-acetate (7.87 g, 19.5 mmol) is suspended in ethanol (20 ml) and is heated at reflux. To the resulting mixture is added 2.5 N aqueous sodium hydroxide (20 ml, 50 mmol). The reaction is heated at reflux with stirring for 1 hour after it becomes homogeneous. The solution is cooled and diluted with ice water (150 ml), then acidified to pH 2 with 6 N aqueous HCl. The resulting precipitate is filtered and dried in vacuo to give 5.06 g (75%) of 1,4,5,10-tetrahydro-7-chloro-3-hydroxy-carbonyl-1-methyl-10-oxobenzocyclohepta[1,2-b]pyrrole-2-acetic acid.

Provenance & Evidence