2-Nitrobenzoyl chloride → Ethyl 1,3-dimethyl-2-(2-nitrobenzoyl)-pyrrole-5-acetate

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Reaction Steps

A solution of 5.7 g (0.032 mole) of ethyl 1,4-dimethylpyrrole-2-acetate and 7.0 g (0.038 mole) of 2-nitrobenzoyl chloride in 130 ml xylene is heated at reflux under nitrogen for 18 hours. The mixture is stirred vigorously over a saturated sodium bicarbonate solution for 3 hours at room temperature. The xylene layer is separated from the aqueous layer, washed with brine, dried and filtered. The filtrate is concentrated in vacuo to give 9.9 g (95%) crude ethyl 1,3-dimethyl-2-(2-nitrobenzoyl)-pyrrole-5-acetate which can be used without further purification in the next step.

Provenance & Evidence