6-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine → 2-(1-Methyl-2,4-diphenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine

HRID 32544Notes

Reaction equation

HRID 32544 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[S:8][C:9]3[N:10]=[CH:11][N:12]=[C:13](S(C)(=O)=O)[C:14]=3[N:15]=2)=[C:5]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:4]=[C:3]1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.C[N:33]1C(C2SC3N=CN=C(S(C)(=O)=O)C=3C=2)=C(C2C=CC=CC=2)N=C1>>[CH3:1][N:2]1[C:6]([C:7]2[S:8][C:9]3[N:10]=[CH:11][N:12]=[C:13]([NH2:33])[C:14]=3[N:15]=2)=[C:5]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:4]=[C:3]1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 179657746-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidineHCID 691963982-(1-Methyl-2,4-diphenyl-1H-imidazol-5-yl)-7-(methylsulfonyl)[1,3]thiazolo[5,4-d]pyrimidine2×

Product 1

HCID 100229082-(1-Methyl-2,4-diphenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine

Procedure

The title compound was prepared by a similar process to that described for Example 8 but using 2-(1-Methyl-2,4-diphenyl-1H-imidazol-5-yl)-7-(methylsulfonyl)[1,3]thiazolo[5,4-d]pyrimidine (Intermediate 40) in place of 6-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine (intermediate 17). Yellow solid (21 mg, 91%);

Sources & evidence

ORD record
ord-b60fb6ed9dab44ab91df60d3d6f4e346
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

Loading…