Thiourea → HCID 178470272, compound

HRID 325449Notes

Reaction equation

HRID 325449 reaction equation
[NH2:1][C:2](N)=[S:3].[CH2:5]([O:7][C:8]([C:10]1[N:11]=[CH:12][N:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)N=C(Cl)[C:14]=12)=[O:9])[CH3:6]>>[CH2:5]([O:7][C:8]([C:10]1[N:11]=[CH:12][N:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:1]=[C:2]([SH:3])[C:14]=12)=[O:9])[CH3:6]

Participants

3

Reactant 2

HCID 2723790ThioureaHCID 13309912HCID 13309912, compound

Product 1

HCID 178470272HCID 178470272, compoundYield 67.2%

Procedure

To an ethanolic solution (200 ml) of 4-chloroimidazo [1,5-a]quinoxaline 3-carboxylic acid ethyl ester (4.8 g) was added thiourea (1.5 g). The mixture was heated on steam bath for one hour. After cooling to room temperature, the precipitated product was collected as a yellowish crystalline solid (3.2 g, 67% yield). Recrystallized from methanol-chloroform, m.p. 251°-253° C.

Workup

  1. temperatureThe mixture was heated on steam bath for one hour

Sources & evidence

ORD record
ord-ed654ffc7d2246b5bf58bb3b00a3d2ca
Source dataset
uspto-grants-1984_04
Patent number
US04440929

Reaction notes

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