HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Amino-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Chloro-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester | HCID 54209491 | — |
| Solvent | Chloroform ethanol | HCID 21889567 | — |
| Product | 4-Amino-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester | HCID 13309917 | 57% |
Reaction Steps
A small stream of anhydrous ammonia was passed through a solution of 4-chloro-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester (5.4 g) in chloroform-ethanol (100 ml each) for 30 minutes. The precipitate was collected and recrystallized from DMF to give the product as an off-white crystalline solid (2.9 g, 57% yield), m.p. >300° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04440929 |
| Source dataset | uspto-grants-1984_04 |
| ORD ID | ord-3ad0da183781423d81bd1213231b7b04 |
| Source note | uspto-grants-1984_04 |