Tert-butyl 2-(cyclopentylamino)acetate → HCID 20465235, compound

Participants

Reaction Steps

3-Chloroacetylsalicylic acid was combined with N-cyclopentylglycine t-butyl ester and N,N1 -dicyclohexylcarbodiimide at 0° C. in methylene chloride as described in Example I. Similar workup gave crude N-(3-chloroacetylsalicyloyl)-N-cyclopentylglycine t-butyl ester, which was cleaved to N-(3-chloroacetylsalicyloyl)-N-cyclopentylglycine using iodotrimethylsilane prepared in situ as described in Example I. Hydrolysis with aqueous sodium hydroxide (Example IV) provided the title compound.

Provenance & Evidence