6-Chloro-2-picoline → 3-({4-[(Piperidin-1-yl)methyl]pyridin-2-yl}oxy)propan-1-amine

HRID 325511Notes

Reaction equation

HRID 325511 reaction equation
N1(C[C:8]2[N:13]=[C:12]([O:14][CH2:15][CH2:16][CH2:17][NH2:18])[CH:11]=[CH:10][CH:9]=2)CCCCC1.Cl[C:20]1[CH:25]=[CH:24][CH:23]=[C:22](C)[N:21]=1.Br[C:28]1C=C(C)C=CN=1>>[N:21]1([CH2:28][C:10]2[CH:9]=[CH:8][N:13]=[C:12]([O:14][CH2:15][CH2:16][CH2:17][NH2:18])[CH:11]=2)[CH2:20][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 876016-Chloro-2-picolineHCID 27340872-Bromo-4-methylpyridineHCID 134915003-({6-[(Piperidin-1-yl)methyl]pyridin-2-yl}oxy)propan-1-amine

Product 1

HCID 146251023-({4-[(Piperidin-1-yl)methyl]pyridin-2-yl}oxy)propan-1-amine

Procedure

When the general procedure for the preparation of 3-(6-piperidinomethyl-2-pyridyloxy)propylamine described in U.K. Patent Application No. 2,098,988 was followed except that the 2-chloro-6-methylpyridine utilized therein was replaced by 2-bromo-4-methylpyridine, then the title compound was produced as an oil.

Sources & evidence

ORD record
ord-58161e9ac5f744ef953661596273d0c6
Source dataset
uspto-grants-1984_04
Patent number
US04440933

Reaction notes

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