HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-({4-[(Piperidin-1-yl)methyl]pyridin-2-yl}oxy)propan-1-amine → 3-Amino-4-[3-(4-piperidinomethyl-2-pyridyloxy)propylamino]-1,2,5-thiadiazole 1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-({4-[(Piperidin-1-yl)methyl]pyridin-2-yl}oxy)propan-1-amine | HCID 14625102 | — |
| Reactant | 3-Amino-4-methoxy-1,2,5-thiadiazole 1-oxide | HCID 15961216 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-4-[3-(4-piperidinomethyl-2-pyridyloxy)propylamino]-1,2,5-thiadiazole 1-oxide | HCID 15961341 | 66.8% |
Reaction Steps
A solution of the product of Step A (6.5 g; 26.0 mmoles) in 90 ml of methanol was reacted with 3-amino-4-methoxy-1,2,5-thiadiazole 1-oxide (3.84 g; 26.0 mmoles) according to the general procedures described in U.S. Pat. No. 4,374,248 to give 6.33 g of product. Recrystallization from methanolacetonitrile yielded the title compound, mp 154°-158° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04440933 |
| Source dataset | uspto-grants-1984_04 |
| ORD ID | ord-5f36d9bc7ccd4108947756579e4dc383 |
| Source note | uspto-grants-1984_04 |