CHEMBL8982 → HCID 13458067, compound

HRID 325515Notes

Reaction equation

NC1C(NCCSCC2C=C(CN(C)C)SC=2)=NS(=O)N=1.[NH2:22][C:23]1[C:27]([NH:28][CH2:29][CH2:30][S:31][CH2:32][C:33]2[O:34][C:35]([CH2:38][N:39]([CH3:41])[CH3:40])=[CH:36][CH:37]=2)=[N:26][S:25](=O)[N:24]=1>>[NH2:22][C:23]1[C:27]([NH:28][CH2:29][CH2:30][S:31][CH2:32][C:33]2[O:34][C:35]([CH2:38][N:39]([CH3:41])[CH3:40])=[CH:36][CH:37]=2)=[N:26][S:25][N:24]=1

Participants

Reactant 2

HCID 5384819CHEMBL8982

HCID 23312529HCID 23312529, compound

Product 1

HCID 13458067HCID 13458067, compound

Procedure

The general procedure of Example 5 is repeated except that the 3-amino-4-{2-[(5-dimethylaminomethyl-3-thienyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide utilized therein is replaced by an equimolar amount of 3-amino-4-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethylamino}-1,2,5-thiadiazole 1-oxide [prepared according to U.S. Pat. No. 4,374,248], and the title compound is thereby produced. Treatment of a portion of the product with an equivalent amount of 2 N HCl in methanol produces the hydrochloride salt of the title compound.

Workup

customprepared

Sources & evidence

ORD record: ord-115a0ef476254c889164d7901131382f
Source dataset: uspto-grants-1984_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04440933

Reaction notes

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