Thionyl Chloride → 2-(4-Fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride

Participants

Reaction Steps

4'-Fluoro-2-hydroxymethyl-3,3',5-trimethyl-1,1'-biphenyl (2.77 g, 11.3 mmoles) was added in divided portions to thionyl chloride (10 ml) and then heated with stirring in an 80° bath for one hour. The reaction was then diluted with 50 ml of dry toluene and the solvent was evaporated in vacuo to leave 3.27 g of the title compound.

Provenance & Evidence