6-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine → 6-[4-(4-Fluorophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	6-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine	HCID 17965774	—
Reactant	6-[4-(4-Fluorophenyl)-1-methyl-1H-imidazol-5-yl]-4-(methylsulfonyl)thieno[2,3-d]pyrimidine	HCID 69197339	—
Product	6-[4-(4-Fluorophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine	HCID 10019211	—

Reaction Steps

The title compound was prepared by a similar process to that described for Example 8 but using 6-[4-(4-Fluorophenyl)-1-methyl-1H-imidazol-5-yl]-4-(methylsulfonyl)thieno[2,3-d]pyrimidine (Intermediate 50) in place of 6-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine (intermediate 17). White solid (53 mg, 75%);

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07427616B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-066320e321444c0e9d670c9f7d5980b6
Source note	uspto-grants-2008_09