Ammonia → 2-Chlorobenzenesulfonamide

HRID 325590Notes

Reaction equation

HRID 325590 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](Cl)(=[O:10])=[O:9].[NH3:12]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:12])(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 761872-Chlorobenzenesulfonyl chloride

Product 1

HCID 814102-Chlorobenzenesulfonamide

Conditions

Temperature
70 °C

Procedure

2-Chlorobenzenesulphonyl chloride (58 g) in either (60 ml) was added dropwise with stirring to concentrated ammonia solution (575 ml). When addition was complete, the mixture was stirred and heated at 70° C. for 1 hour. The mixture was then cooled and the solid filtered off, washed with water, and dried to give the required 2-chlorobenzenesulphonamide (39 g) with a melting point of 186° C.

Workup

  1. additionWhen addition
  2. temperatureThe mixture was then cooled
  3. filtrationthe solid filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-2c4fc387f06e43118ed9fb970cddaad3
Source dataset
uspto-grants-1984_04
Patent number
US04441917

Reaction notes

Loading…