反应详情

温度

0 °C

22.1 g of 2-(2,6-dichlorobenzyloxy)ethanol and 10.1 g of triethylamine were dissolved in 200 ml of toluene, then cooled to 0° C. To this solution was dropwise added a solution of 34.5 g of 2-[4-(4-trifluoromethylphenoxy)phenoxy]propionyl chloride in 50 ml of toluene at 0° to 10° C. After the dropwise addition, the reaction mixture was gradually heated and, at 40° C., it was stirred for one hour to complete the reaction. After cooling the reaction solution to room temperature, it was washed successively with 1% strength by weight sodium hydroxide aqueous solution and water, then dehydrated. After distilling off toluene under reduced pressure, the resulting colorless, viscous, oily product was allowed to stand for about 1 month to obtain 49.2 g of crystalline 2-(2,6-dichlorobenzyloxy)ethyl 2-[4-(4-trifluoromethylphenoxy)phenoxy]propionate. m.p. 51° to 53° C.

1. additionAfter the dropwise addition
2. temperaturethe reaction mixture was gradually heated and, at 40° C.
3. customthe reaction
4. temperatureAfter cooling the reaction solution to room temperature
5. washit was washed successively with 1% strength by weight sodium hydroxide aqueous solution and water
6. distillationAfter distilling off toluene under reduced pressure
7. waitto stand for about 1 month