Succinic anhydride → HCID 70464371, compound

Participants

Reaction Steps

After 5 g of 7-ketocholesterol was dissolved in 50 ml pyridine, 1.8 g of succinic anhydride was added thereto, the mixture was heated to react for 8 hours at 90° C. and allowed to stand at room temperature overnight. Then, the resulting liquid was poured into 500 ml ice-cold water. The crystals precipitated by acidification with hydrochloric acid were collected by filtration and then dissolved in ethanol, active carbon was added thereto for decoloration and filtered off, water was added to the filtrate, and the precipitated crystals were recovered by filtration. Upon recrystallization thereof from aqueous ethanol, 5.4 g of 7-ketocholesterol succinic acid half ester was obtained as flaky crystals, m.p. 187.5°-189.5° C.

Provenance & Evidence