反应详情

温度

160 °C

A mixture of 2-(3,4-diethoxyphenyl)-ethylamine (40.7 g, 0.195 mole) and ethyl 3,4-diisopropoxyphenylacetate (55.7 g, 0.195 mole) was heated with stirring at 160° C. for 20 hours, allowed to cool and the resulting oil taken up in 700 ml of chloroform. The organic solution was washed 3 times with 100 ml of N hydrochloric acid and then with water to pH 7. The chloroform solution was dried over magnesium sulphate, the solvent removed under reduced pressure and purification effected by chromatography over silica gel. 64.5 g (yield 72%) of product was obtained sufficiently pure to be used in step (b) below.

1. temperaturewas heated
2. temperatureto cool
3. washThe organic solution was washed 3 times with 100 ml of N hydrochloric acid
4. dry with materialThe chloroform solution was dried over magnesium sulphate
5. customthe solvent removed under reduced pressure and purification