反应详情

A solution of thionyl chloride (2.32 g.) in dichloromethane (100 ml.) was added during 1.5 hours to a refluxing suspension of finely ground 3-hydroxymethyl-1-methyl-7-trifluoromethyl-4-quinolone (5.0 g.) in dichloromethane (200 ml). The solution was boiled under reflux for a further 0.5 hours then evaporated to dryness under reduced pressure to give the novel 3-chloromethyl-1-methyl-7-trifluoromethyl-4-quinolone hydrochloride, m.p. 182°-189°.

1. temperatureunder reflux for a further 0.5 hours
2. customthen evaporated to dryness under reduced pressure