Dimethyl Sulfate → HCID 12807883, compound

Participants

Reaction Steps

In a similar manner to that described in Example 3 7-chloro-4-hydroxy-3-hydroxymethylquinoline was treated with dimethyl sulphate to give the novel 7-chloro-1-methyl-3-hydroxymethyl-4-quinolone, m.p. 204°-206° (from industrial methylated spirit). Reaction of this product with thionyl chloride gave 7-chloro-3-chloromethyl-1-methyl-4-quinolone hydrochloride, m.p. 205°-207°, which was reacted with sodium methanethiolate to give the novel 7-chloro-1-methyl-3-methylthiomethyl-4-quinolone, m.p. 163°-164° (from industrial methylated spirit).

Provenance & Evidence