Formaldehyde → HCID 178487717, compound

HRID 325635Notes

Reaction equation

HRID 325635 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH2:14]=[O:15]>[OH-].[Na+]>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[CH2:14][OH:15]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 178487715HCID 178487715, compound

Product 1

HCID 178487717HCID 178487717, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4-Hydroxy-7-methoxyquinoline was reacted with formaldehyde in aqueous sodium hydroxide (initially at 40°-50°, then kept at 60° for 18 hours) to give the novel compound 4-hydroxy-3-hydroxymethyl-7-methoxyquinoline, m.p. 291°-297°.

Sources & evidence

ORD record
ord-1289c072717048178186dd98b7add0b2
Source dataset
uspto-grants-1984_04
Patent number
US04442109

Reaction notes

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