Sodium Hydroxide → HCID 178435556, compound

Participants

Reaction Steps

A stirred mixture of ethyl 7-ethyl-4-hydroxyquinoline-3-carboxylate and 5 M aqueous sodium hydroxide solution was heated to reflux. When all the solids had dissolved the solution was boiled for a further 30 minutes, cooled, and acidified to pH 4.0 with glacial acetic acid (30 ml.). The solid was collected, washed with water until the washings were neutral, and dried to give the novel compound 7-ethyl-4-hydroxyquinoline-3-carboxylic acid, m.p. 175°-178°.

Provenance & Evidence