Formaldehyde → 6-Chloro-3-(hydroxymethyl)-4-quinolinol

HRID 325644Notes

Reaction equation

HRID 325644 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[OH:12].[CH2:13]=[O:14]>[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([CH2:13][OH:14])=[C:5]2[OH:12]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 178516411HCID 178516411, compound

Product 1

HCID 1785198076-Chloro-3-(hydroxymethyl)-4-quinolinol

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

6-Chloro-4-hydroxyquinoline was reacted with formaldehyde in aqueous sodium hydroxide at 55° for 24 hours to give the novel compound 6-chloro-4-hydroxy-3-hydroxymethylquinoline, m.p. >300°.

Sources & evidence

ORD record
ord-a8d4065c3837426c8f5df5d6bd0dd9e9
Source dataset
uspto-grants-1984_04
Patent number
US04442109

Reaction notes

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