(3-Iodophenyl)(isocyano)methyl 4-methylphenyl sulfone → 6-(4-(3-iodophenyl)-1-methyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine

Participants

Reaction Steps

The title compound was prepared by a similar process to that described for Example 6 but using N-[4-(methylthio)thieno[2,3-d]pyrimidin-6-ylmethylidene]methanamine (Intermediate 16) in place of N-(3,4-Dimethoxybenzyl)-N-[thieno[2,3-d]pyrimidin-6-ylmethylidene]amine (intermediate 14) and using (3-iodophenyl)(isocyano)methyl 4-methylphenyl sulfone (Intermediate 53) in place of PhTosMIC. Pale yellow solid (1.50 g, 71%);

Provenance & Evidence