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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 325653Generated: October 30, 2026

Formaldehyde → HCID 178503657, compound

https://huagongshe.com/reaction/325653

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
ReactantMethanethiolHCID 878—
ReactantTriethylamineHCID 8471—
Reactantquinolin-4-olHCID 178516385—
SolventIsopropanolHCID 3776—
ProductHCID 178503657HCID 178503657—

Reaction Steps

In a similar way to that described in Example 18, 4-hydroxyquinoline was reacted with 40% aqueous formaldehyde and methanethiol in the presence of triethylamine to give the novel 4-hydroxy-3-methylthiomethylquinoline, m.p. 196°-197° (from isopropanol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04442109
Source datasetuspto-grants-1984_04
ORD IDord-cde9d53a259b41c5bb7fa7c62661e625
Source noteuspto-grants-1984_04