HCID 23322141, compound → HCID 23322139, compound

HRID 325665Notes

Reaction equation

HRID 325665 reaction equation
[BrH:1].[CH2:2]([N:5]([CH2:20][CH2:21][CH3:22])[CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:19])[C:12]=2[N+:16]([O-])=O)[CH2:7]1)[CH2:3][CH3:4]>C(O)C.[Pd]>[BrH:1].[CH2:20]([N:5]([CH2:2][CH2:3][CH3:4])[CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:19])[C:12]=2[NH2:16])[CH2:7]1)[CH2:21][CH3:22]

Participants

4

Reactant 1

HCID 23322141HCID 23322141, compound

Product 1

HCID 23322139HCID 23322139, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

7 g of 2-dipropylamino-6-hydroxy-5-nitro-1,2,3,4-tetrahydronaphthalene hydrobromide are suspended in 250 ml of ethanol and hydrogenation is carried out at ambient temperature, in the presence of 1 g of 5% palladium-on-charcoal, under a pressure of about 0.3 MPa. The solvent is then evaporated off and the residue is triturated in diethyl ether. The product obtained melts at 215°-218° C. (with decomposition).

Workup

  1. customThe solvent is then evaporated off
  2. customthe residue is triturated in diethyl ether
  3. customThe product obtained melts at 215°-218° C. (with decomposition)

Sources & evidence

ORD record
ord-637bf1f4356e44cfb653bc3cb35211ae
Source dataset
uspto-grants-1984_04
Patent number
US04442126

Reaction notes

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