Nitric Acid → HCID 20463977, compound

Participants

Reaction Steps

12.2 g of 2-propanoylamino-6-methoxy-1,2,3,4-tetrahydronaphthalene are introduced into 100 ml of trifluoroacetic acid, and 3 ml of nitric acid (d=1.49) are added dropwise thereto. Stirring is continued for 8 hours and the mixture is then taken up in water and diethyl ether. To separate the nitro isomers, the mixture is subjected to chromatography under pressure, on a silica column, elution being carried out with an 8/2 methylene chloride/ethyl acetate mixture. 5 g of the isomer nitrated in the 7-position and 3.8 g of the isomer nitrated in the 5-position are finally collected.

Provenance & Evidence