Formic Acid → HCID 20463970, compound

HRID 325677Notes

Reaction equation

HRID 325677 reaction equation
[BrH:1].[CH2:2]([NH:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:17])[C:12]=2[NH2:16])[CH2:7]1)[CH2:3][CH3:4].[CH:18](O)=[O:19].C(OC(=O)C)(=O)C>C(OCC)C>[BrH:1].[CH2:2]([NH:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:17])[C:12]=2[NH:16][CH:18]=[O:19])[CH2:7]1)[CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 20463973HCID 20463973, compound

Product 1

HCID 20463970HCID 20463970, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.9 g of 2-propylamino-5-amino-6-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide are introduced into a mixture of 6 ml of formic acid and 0.67 ml of acetic anhydride, kept in an ice-bath for 1/2 hour. The mixture is stirred for 3 hours at ambient temperature and then poured into diethyl ether. The precipitate which has formed is filtered off and washed with hot isopropyl alcohol. After drying, 1.7 g of the final compound are obtained, which melts at 210° C.

Workup

  1. customThe precipitate which has formed
  2. filtrationis filtered off
  3. washwashed with hot isopropyl alcohol
  4. customAfter drying

Sources & evidence

ORD record
ord-23ceaac9a5964fdeb299150fa16f6b5a
Source dataset
uspto-grants-1984_04
Patent number
US04442126

Reaction notes

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