1-Bromo-3-(isocyano(tosyl)methyl)benzene → 6-[4-(3-bromophenyl)-1-methyl-1H-imidazol-5-yl]-4-(methylthio)thieno[2,3-d]pyrimidine

Participants

Reaction Steps

The title compound was prepared by a similar process to that described for Example 6 but using N-[4-(methylthio)thieno[2,3-d]pyrimidin-6-ylmethylidene]methanamine (Intermediate 16) in place of N-(3,4Dimethoxybenzyl)-N-[thieno[2,3-d]pyrimidin-6-ylmethylidene]amine (intermediate 14) and using ((3-bromophenyl)(isocyano)methyl 4-methylphenyl sulfone (Intermediate 57) in place of PhTosMIC. Foam (1.9 g, 91%);

Provenance & Evidence