Trifluoroacetic acid → HCID 178436818, compound

Participants

Reaction Steps

A mixture of 3'-acetyl-5'-ethyl-2'-hydroxy-1-(4-methoxybenzyl)-1H-tetrazole-5-carboxanilide (0.41 g), trifluoroacetic acid (15 ml) and methoxybenzene (1.0 g) was heated at reflux for 45 minutes. The mixture was then cooled, and the solvents were removed under reduced pressure. The residue was treated with aqueous ammonia (2 N; 10 ml), washed with diethyl ether (10 ml), and the aqueous layer was separated off, cooled in an ice-bath and acidified by treatment with concentrated hydrochloric acid. The resulting solid was filtered off to give 3'-acetyl-5'-ethyl-2'-hydroxytetrazole-5-carboxanilide (30 mg), m.p. 238°-240° C. (with decomposition).

Provenance & Evidence