Hydrochloric Acid → HCID 136399284, compound

Participants

Reaction Steps

A solution of 3'-acetyl-2'-hydroxy-1-(4-methoxybenzyl)-5'-nitro-1H-tetrazole-5-carboxanilide (2.06 g) in a solution of hydrogen chloride in ethanol (0.36 N; 60 ml) was hydrogenated at atmospheric pressure and at 25° C., using a 5% w/w palladium on charcoal catalyst (0.5 g), during a period of 150 minutes. The catalyst was then filtered off and the filtrate was evaporated in vacuo. The resulting residue was recrystallised from ethanol to give 3'-acetyl-5'-amino-2'-hydroxy-1-(4-methoxybenzyl)-1H-tetrazole-5-carboxanilide hydrochloride (1.2 g), in the form of colourless crystals, m.p. 225° C. (with decomposition).

Provenance & Evidence