HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl cyanoformate → ethyl 1-(4-methoxybenzyl)-1H-tetrazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl cyanoformate | HCID 69336 | — |
| Reactant | 1-(Azidomethyl)-4-methoxybenzene | HCID 10931767 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | ethyl 1-(4-methoxybenzyl)-1H-tetrazole-5-carboxylate | HCID 11097352 | 95.3% |
Reaction Steps
A mixture of crude 4-methoxybenzyl azide (45.3 g; prepared as described below) and ethyl cyanoformate (33 g) in xylene (300 ml) was heated at reflux for 48 hours. The mixture was evaporated at below 40° C. and under reduced pressure to leave a residue of ethyl 1-(4-methoxybenzyl)-1H-tetrazole-5-carboxylate (69.36 g), m.p. 52° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04442115 |
| Source dataset | uspto-grants-1984_04 |
| ORD ID | ord-37265387fae74eff98b258c00dbba15b |
| Source note | uspto-grants-1984_04 |