反应详情

A solution of fuming nitric acid (12.1 ml; s.g. 1.5) in glacial acetic acid (120 ml) was added in one portion to a stirred solution of 4-ethyl-2-methoxyphenol (41.7 g) in dry dichloromethane (800 ml). After 1 minute the solution was washed with water (3×300 ml), and the organic layer was dried over anhydrous sodium sulphate and evaporated in vacuo to give an orange crystalline residue. This was recrystallised from a mixture of methanol and water to give 4-ethyl-2-methoxy-6-nitrophenol (31.3 g), m.p. 59°-61° C.

1. washAfter 1 minute the solution was washed with water (3×300 ml)
2. dry with materialthe organic layer was dried over anhydrous sodium sulphate
3. customevaporated in vacuo
4. customto give an orange crystalline residue
5. customThis was recrystallised from a mixture of methanol and water