Benzyl Chloride → HCID 13596237, compound

Participants

Reaction Steps

A mixture of 4-bromo-2-methoxy-6-nitrophenol (7.0 g), anhydrous potassium carbonate (2.12 g) and benzyl chloride (3.93 g) in dry sulpholane (70 ml) was stirred at 90°-95° C. for 24 hours. The mixture was then diluted with water (300 ml) and the resulting oil was extracted with diethyl ether (3×50 ml). The combined ethereal extracts were washed with aqueous sodium carbonate solution (2 N; 2×50 ml) and then with water (3×20 ml), dried over anhydrous sodium sulphate and evaporated in vacuo to give a solid, which was recrystallised from ethanol to give 2-benzyloxy-5-bromo-3-methoxynitrobenzene (7.7 g), m.p. 74°-76° C.

Provenance & Evidence