Ethanol → HCID 13596231, compound

HRID 325748Notes

Reaction equation

HRID 325748 reaction equation
[OH:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([CH3:14])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.O.[CH2:21](O)[CH3:22]>>[OH:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([CH3:14])=[CH:7][C:3]=1[C:4]([O:6][CH2:21][CH3:22])=[O:5]

Participants

5

Reactant 4

HCID 702EthanolHCID 962WaterHCID 1118Sulfuric AcidHCID 125712772-Hydroxy-5-methyl-3-nitrobenzoic acid

Product 1

HCID 13596231HCID 13596231, compound

Procedure

2-Hydroxy-5-methyl-3-nitrobenzoic acid (10.0 g) was dissolved in absolute ethanol (50 ml) and the solution was treated with concentrated sulphuric acid (3.0 ml), slowly with stirring. The mixture was heated at reflux for 20 hours and then poured into water (250 ml). The resulting yellow solid was recrystallised from ethanol to give ethyl 2-hydroxy-5-methyl-3-nitrobenzoate (7.5 g), m.p. 97° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 20 hours
  3. customThe resulting yellow solid was recrystallised from ethanol

Sources & evidence

ORD record
ord-65e4fcd4abf742018da7d4899b4d5aac
Source dataset
uspto-grants-1984_04
Patent number
US04442115

Reaction notes

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