反应详情

1-Morpholinocyclopentene (30 g; 0.2 mole) was mixed with phosphorous acid (16.4 g; 0.2 mole) and heated with stirring. As the temperature reached 70° an exothermic process took place taking the internal temperature to 105°. The viscosity of the reaction mixture increased as the reaction proceeded. After maintaining at 100°-105° for 30 mins. the reaction mixture was diluted and basified. Extraction with chloroform yielded N-cyclopentylmorpholine (72%). The product was characterized by 13C and 1H nmr spectra. ##STR16##

1. temperatureheated
2. customreached 70°
3. customto 105°
4. temperatureThe viscosity of the reaction mixture increased as the reaction
5. temperatureAfter maintaining at 100°-105° for 30 mins
6. additionthe reaction mixture was diluted
7. extractionExtraction with chloroform