a-Tosyl-(4-bromobenzyl) isocyanide → 6-[4-(4-bromophenyl)-1-methyl-1H-imidazol-5-yl]4-(methylthio)thieno[2,3-d]pyrimidine

Participants

Reaction Steps

The title compound was prepared by a similar process to that described for Example 6 but using N-[4-(methylthio)thieno[2,3-d]pyrimidin-6-ylmethylidene]methanamine (Intermediate 16) in place of N-(3,4-Dimethoxybenzyl)-N-[thieno[2,3-d]pyrimidin-6-ylmethylidene]amine. (intermediate 14) and (4-bromophenyl)(isocyano)methyl 4-methylphenyl sulfone (Intermediate 66) in place of PhTosMIC. Pale yellow solid (1.7 g, 81%);

Provenance & Evidence