Sulfuric Acid → HCID 54488538, compound

Participants

Reaction Steps

A solution of 2.2 g of 3',5'-bis-(4-pivaloyloxybenzoyloxy)-2-cyclobutylamino acetophenone hydrochloride in 75 ml of ethanol was hydrogenated at 380 kPa (55 psig) and 45° C. for 18 hrs in the presence of 0.4 g 10% Pd/C. After filtering off the catalyst the filtrate was evaporated to dryness to give an oil as residue. This oil was partitioned between ethyl ether and 10% sodium carbonate solution. The ether phase was dried over MgSO4, filtered and evaporated to dryness to give a crystalline residue. The residue was dissolved in ethanol which was acidified with ethanolic sulphuric acid to pH 5.5. After evaporation, the residue was recrystallized from isopropanol/ethyl ether. The identity of the product was confirmed with NMR.

Provenance & Evidence