6-(1-Methylphenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidine → 6-[4-(4-Bromophenyl)-1-methyl-1H-imidazol-5-yl]-4-(methylsulfonyl)thieno[2,3-d]pyrimidine

HRID 32580Notes

Reaction equation

HRID 32580 reaction equation
C[C:2]1([N:8]2[C:12]([C:13]3[S:25][C:16]4[N:17]=[CH:18][N:19]=[C:20]([S:21]([CH3:24])(=[O:23])=[O:22])[C:15]=4[CH:14]=3)=[CH:11][N:10]=[CH:9]2)C=CC=CC1.[Br:26][C:27]1[CH:32]=[CH:31][C:30](C2N=CN(C)C=2C2SC3N=CN=C(SC)C=3C=2)=[CH:29][CH:28]=1>>[Br:26][C:27]1[CH:32]=[CH:31][C:30]([C:11]2[N:10]=[CH:9][N:8]([CH3:2])[C:12]=2[C:13]2[S:25][C:16]3[N:17]=[CH:18][N:19]=[C:20]([S:21]([CH3:24])(=[O:22])=[O:23])[C:15]=3[CH:14]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 691941946-(1-Methylphenyl-1H-imidazol-5-yl)-4-(methylsulfonyl)thieno[2,3-d]pyrimidineHCID 691957936-[4-(4-bromophenyl)-1-methyl-1H-imidazol-5-yl]4-(methylthio)thieno[2,3-d]pyrimidine2×

Product 1

HCID 691959566-[4-(4-Bromophenyl)-1-methyl-1H-imidazol-5-yl]-4-(methylsulfonyl)thieno[2,3-d]pyrimidine

Procedure

The title compound was prepared by a similar process to that described for Intermediate 17 but using 6-[4-(4-bromophenyl)-1-methyl-1H-imidazol-5-yl]4-(methylthio)thieno[2,3-d]pyrimidine (Intermediate 67) in place of 6-(1-methyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine (example 7). Pale yellow solid (715 mg, 79%);

Sources & evidence

ORD record
ord-63971e087fa44165a93f46f6cc2ccf2b
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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