HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 325800Generated: October 30, 2026
Propargyl bromide → 5-Methyl-2-propargyloxyphenylsulfonamide
https://huagongshe.com/reaction/325800
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Hydroxy-5-methylbenzenesulfonamide | HCID 13321753 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-Methyl-2-propargyloxyphenylsulfonamide | HCID 13472948 | — |
Reaction Steps
A mixture of 24.3 g of 2-hydroxy-5-methylphenylsulfonamide, 36.0 g of potassium carbonate, 16.7 g of propargyl bromide and 500 ml of acetonitrile is stirred at 50° C. for 4.5 hours. The reaction mixture is then filtered, and concentrated by evaporation. The yield after recrystallisation from ethyl acetate is 23.9 g of 5-methyl-2-propargyloxyphenylsulfonamide, m.p. 169°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04443243 |
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| Source dataset | uspto-grants-1984_04 |
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| ORD ID | ord-d53deda4f1d5454b91096332035a5f37 |
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| Source note | uspto-grants-1984_04 |
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