2-Propyl-6-heptenoic acid → 7-Acetylthio-2-propylheptanoic acid

HRID 325815Notes

Reaction equation

HRID 325815 reaction equation
[CH2:1]([CH:4]([CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12])[C:5]([OH:7])=[O:6])[CH2:2][CH3:3].[C:13]([OH:16])(=[S:15])[CH3:14]>>[C:13]([S:15][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH:4]([CH2:1][CH2:2][CH3:3])[C:5]([OH:7])=[O:6])(=[O:16])[CH3:14]

Participants

3

Reactant 2

HCID 204628752-Propyl-6-heptenoic acidHCID 178418634HCID 178418634, compound

Product 1

HCID 204628707-Acetylthio-2-propylheptanoic acidYield 62.2%

Conditions

Temperature
60 °C

Procedure

A mixture of 2-propyl-6-heptenoic acid (1 g) and thioacetic acid (450 mg) was heated for 4 hours at 60° C. and allowed to stand overnight at ambient temperature in an air-tight container. Excess thioacetic acid was evaporated under reduced pressure to give oil of 7-acetylthio-2-propylheptanoic acid (0.9 g).

Workup

  1. customExcess thioacetic acid was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9d19a36a597e449fa354e06be365c250
Source dataset
uspto-grants-1984_04
Patent number
US04443365

Reaction notes

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