Cyclopropylamine → 6-(1-cyclopropyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine

HRID 32584Notes

Reaction equation

[CH2:1]([N:3]1[C:7]([C:8]2[S:18][C:11]3[N:12]=[CH:13][N:14]=[C:15]([S:16][CH3:17])[C:10]=3[CH:9]=2)=[C:6]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:5]=[CH:4]1)[CH3:2].[CH:25]1(N)CC1>>[CH:1]1([N:3]2[C:7]([C:8]3[S:18][C:11]4[N:12]=[CH:13][N:14]=[C:15]([S:16][CH3:17])[C:10]=4[CH:9]=3)=[C:6]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:5]=[CH:4]2)[CH2:25][CH2:2]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 691949276-(1-ethyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine

Product 1

HCID 691961746-(1-cyclopropyl-4-phenyl-1H-imidazol-5-yl)-4-(methylthio)thieno[2,3-d]pyrimidine

Procedure

The title compound was prepared by a similar process to that described for Intermediate 70 but using cyclopropylamine in place of ethylamine. Solid (25 mg, 14%) (contains 30% of 1-cyclopropyl-4,5-phenyl-1H-imidazole);

Sources & evidence

ORD record: ord-989f101a26004238aae7adec937d6677
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07427616B2

Reaction notes

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