反应详情

温度

25 °C

N-acetyl-L-cysteine (0.5 g, 3.06 mmol) was dissolved in 50 ml of dry dioxane. Chloromethyl benzamide (0.52 g, 3.06 mmol) was added and the colorless solution was stirred at 25° C. for 18 hours. The dioxane was evaporated under vacuum with minimal amount of heating to give a colorless oil: NMR (CDCl3 +DMSO) δ8.05-7.38 (m, 5, aryl), 4.58 (d, 2, --SCH2NH--), 2.01 (s, 3, --CH3).

1. customThe dioxane was evaporated under vacuum with minimal amount
2. temperatureof heating
3. customto give a colorless oil