Sodium Hydroxide → HCID 23686324, compound

HRID 325853Notes

Reaction equation

HRID 325853 reaction equation
[OH-].[Na+:2].[CH3:3][CH:4]1[N:9]2[CH:10]=[C:11]([C:24]([OH:26])=[O:25])[C:12](=[O:23])[C:13]3[CH:14]=[CH:15][C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[C:7]([C:8]=32)[O:6][CH2:5]1>O>[CH3:3][CH:4]1[N:9]2[CH:10]=[C:11]([C:24]([O-:26])=[O:25])[C:12](=[O:23])[C:13]3[CH:14]=[CH:15][C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[C:7]([C:8]=32)[O:6][CH2:5]1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13345730HCID 13345730, compound

Product 1

HCID 23686324HCID 23686324, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a solution of 0.0997 g of sodium hydroxide in 40 ml of water was added 0.8 g of 2,3-dihydro-3-methyl-7-oxo-10-phenyl-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid. The mixture was heated briefly until the carboxylic acid dissolved. The solution was then filtered and the filtrate obtained was then evaporated to provide a residue. The residue was dissolved in 50 ml of water, the solution filtered and the filtrate was lyophilized to provide light tan solid, sodium 2,3-dihydro-3-methyl-7-oxo-10-phenyl-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate, m.p. 236° C. (dec.). Analysis: Calculated for C19H14NNaO4.1.5H2O: %C, 61.6; %H, 4.6; %N, 3.8; Found: %C, 61.4; %H, 4.3; %N, 3.6. The structural assignment was confirmed by infrared spectral analysis.

Workup

  1. dissolutiondissolved
  2. filtrationThe solution was then filtered
  3. customthe filtrate obtained
  4. customwas then evaporated
  5. customto provide a residue
  6. filtrationthe solution filtered

Sources & evidence

ORD record
ord-ded7f175017d4025ac73918dc8cd004c
Source dataset
uspto-grants-1984_04
Patent number
US04443447

Reaction notes

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